• Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Example Micrograph
    • Micrograph slide of protein

welcome

Yale University’s Electron Cryo-Microscopy resources encompass a broad range of Cryo-EM imaging instrumentation dedicated to bringing state of the art technology to bear on the most provocative questions in structural biology research.

Our resources include:

The Titan Krios is the world’s most powerful microscope for three-dimensional characterization of biological molecules. It is optimized for life science applications, enabling the visualization of molecules in atomic detail via both single-particle Cryo-EM and Electron Cryo Tomography.

Our facilities are open to new and experienced users. Please see specifics of each instrument for training and schedule information.

Announcements

Introduction (Michael C. Crair) Overview of Cryo-EM at Yale (Xinran Liu) (Yong Xiong) Introduction to Titan Krios (Shenping Wu) Computational magic behind single-particle Cryo-EM (Fredrick J. Sigworth) From X-Ray crystallography to Cryo-EM: Single-particle applications (Yong Xiong) The future of cryo-electron tomography: Cell biology at high resolution (Jun Liu)
maintenance
Current status:   Operational. Scheduled maintenance: 02/03/2020 - Gatan service, K3 upgrade. Planned maintenance: None. Other works that may interrupt the operation in the future: K3 upgrade Past services
FEG
Jan.02.2017 – Crates arrived Jan. 05. 2017 – Unpacking and installation started Jan.12.2017 – Microscope body rolled into enclosure Feb.10.2017 – The gun beamed for the first time on site Feb.28.2017 – Installation of GIF/K2 started Mar.29.2017 – Sign-off July.01.2017 – Open to Yale community ♦ Photo credit: Chris Incarvito