• Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Example Micrograph
    • Micrograph slide of protein

welcome

Yale University’s Electron Cryo-Microscopy resources encompass a broad range of Cryo-EM imaging instrumentation dedicated to bringing state of the art technology to bear on the most provocative questions in structural biology research.

Our resources include:

The Titan Krios is the world’s most powerful microscope for three-dimensional characterization of biological molecules. It is optimized for life science applications, enabling the visualization of molecules in atomic detail via both single-particle Cryo-EM and Electron Cryo Tomography.

Our facilities are open to new and experienced users. Please see specifics of each instrument for training and schedule information.

Announcements

maintenance
Current status: Operational Scheduled maintenance: None Planned maintenance: Troubleshoot airlock cycle and TEM server crash Fix Falcon3EC defects, possibly replace the sensor Other works that may interrupt the operation in the future: Lay network cables from 059F to 059A and move Falcon data server to 059A. Landscape construction in nearby area, heavy digging. Past services
FEG
Jan.02.2017 – Crates arrived Jan. 05. 2017 – Unpacking and installation started Jan.12.2017 – Microscope body rolled into enclosure Feb.10.2017 – The gun beamed for the first time on site Feb.28.2017 – Installation of GIF/K2 started Mar.29.2017 – Sign-off July.01.2017 – Open to Yale community ♦ Photo credit: Chris Incarvito
Introduction (Michael C. Crair) Overview of Cryo-EM at Yale (Xinran Liu) (Yong Xiong) Introduction to Titan Krios (Shenping Wu) Computational magic behind single-particle Cryo-EM (Fredrick J. Sigworth) From X-Ray crystallography to Cryo-EM: Single-particle applications (Yong Xiong) The future of cryo-electron tomography: Cell biology at high resolution (Jun Liu)