• Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Micrograph slide of protein
    • Example Micrograph
    • Micrograph slide of protein

welcome

Yale University’s Electron Cryo-Microscopy resources encompass a broad range of Cryo-EM imaging instrumentation dedicated to bringing state of the art technology to bear on the most provocative questions in structural biology research.

Our resources include:

The Titan Krios is the world’s most powerful microscope for three-dimensional characterization of biological molecules. It is optimized for life science applications, enabling the visualization of molecules in atomic detail via both single-particle Cryo-EM and Electron Cryo Tomography.

Our facilities are open to new and experienced users. Please see specifics of each instrument for training and schedule information.

Announcements

maintenance
Current status:   3/9/2020 to present - Gatan K3 upgrade. Scheduled maintenance: None. Planned maintenance: Stage service. Other works that may interrupt the operation in the future: None. Past services
FEG
Jan.02.2017 – Crates arrived Jan. 05. 2017 – Unpacking and installation started Jan.12.2017 – Microscope body rolled into enclosure Feb.10.2017 – The gun beamed for the first time on site Feb.28.2017 – Installation of GIF/K2 started Mar.29.2017 – Sign-off July.01.2017 – Open to Yale community ♦ Photo credit: Chris Incarvito
Introduction (Michael C. Crair) Overview of Cryo-EM at Yale (Xinran Liu) (Yong Xiong) Introduction to Titan Krios (Shenping Wu) Computational magic behind single-particle Cryo-EM (Fredrick J. Sigworth) From X-Ray crystallography to Cryo-EM: Single-particle applications (Yong Xiong) The future of cryo-electron tomography: Cell biology at high resolution (Jun Liu)
Please check out opportunities of Titan Krios access at other places when the Yale Krios is undergoing upgrade and maintenance.  NIH free resources: https://cryoem.yale.edu/user-guidelines/national-cryo-em-centers HHMI eligible: Janelia. Other places that are known to accept paid external users (not a complete list):  https://cores.research.asu.edu/materials/equipment/titan-krios-fei https://bsir.bio.fsu.edu/facility-rates https://wucci.wustl.edu/user-info/rates/ https://cryoem.hms.harvard.edu/users https://www.umassmed.edu/research/cores/cryo-em-core-facility/contact/ https://cryoem.bio.purdue.edu/services/index.html http://cryoem.jhmi.edu/scheduling/ https://iac.princeton.edu/equipment.html https://smif.pratt.duke.edu/node/55048 https://cemas.osu.edu/Rates https://case.edu/medicine/research/som-core-facilities/cryo-electron-mic… https://www.med.upenn.edu/electronmicroscopyresourcelab/request-access.html