User guidelines

The Yale Cryo-EM resource (Titan Krios), the Center for Cellular and Molecular Imaging (CCMI) at Yale School of Medicine (Tecnai T12 and TF20, has a training program for beginners), and the Science Hill EM lab (Talos L120C) are integrative components of the Cryo-EM program at Yale University. A range of instruments is available to users to support research at different stages of their projects. Preliminary evaluation is performed utilizing the T12 using negative staining EM. Cryo-EM sample optimization and small scale data collection may be performed at TF20 equipped with a K2 direct detector. The new Talos L120C microscope can be used for both negative staining EM and Cryo-EM sample optimization. The Titan Krios should be primarily used for large-scale data collection on optimized samples.

Yale credentials are required to open some of the documents.

Practical guidelines
Access policy and rates
Access request (long form for new projects)
An example of the long form
Access request (short form for existing projects)

• The price of the consumables is subject to change. Currently, it is $17 per grid.

Computational needs are supported by Center for Research Computing. Please follow their guidelines and instructions.